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Retrieving and screening evidence
Live research / global_health
Investigating the molecular mechanisms and epidemiological spread of artemisinin-resistant Plasmodium falciparum in East Africa, with focus on PfKelch13 C580Y and related mutations.
Progress summary
Project initialized with seven field-level ghost questions, a tiered task decomposition, and a protein viewer path for PfKelch13 resistance mutations.
Published-data research case study
A linked partial reanalysis of PIN and LMD source-labelled haplotypes in Ugandan malaria data. Inspect assay results, methods, source provenance, and the missing inputs needed for a full reproduction.
Open PX1 case studyCross-field evidence program
Cathedral searches dated malaria literature alongside older work on bacterial persistence, cancer drug tolerance, and stress-response mechanisms. Indexed matches are leads, not validated transfers; source passages, prior art, and independent review are required before any connection is published.
The program ledger is temporarily unavailable.
Start here / no biology credential required
Cathedral does not claim one person can solve resistance from a browser. It makes the research legible, separates safe beginner work from specialist judgment, keeps every claim attached to evidence, and routes the hard decisions to biologists, clinicians, epidemiologists, and monitored agents.
1 / Orient
Read the ELI5 concept layer for malaria, ACT treatment, K13, and delayed parasite clearance.
2 / Search
Choose an open question and pull live PubMed, Europe PMC, Semantic Scholar, Crossref, and arXiv evidence.
3 / Contribute
Audit study location, mutation, regimen, outcome, and source passage in a structured evidence table.
4 / Validate
Send disputed interpretations and proposed interventions to domain experts; agents handle repeatable surveillance.
Structural biology
Wildtype structures load from AlphaFold DB. Resistance mutants are folded with ESMFold and rendered inline so molecular hypotheses can sit beside the literature.
Ghost nodes
The structural and biochemical reason C580Y is so successful as a resistance mechanism remains unresolved.
Open canonical question record
The complete pathway connecting K13 function to heme release and artemisinin activation remains disputed.
Open canonical question record
The epidemiological and genomic reasons for this asymmetry remain unexplained.
Open canonical question record
Daily progress log
2026-07-06
Initialized Cathedral's public artemisinin-resistance research project and protein-structure workbench.
Blocked: MalariaGEN and WWARN adapters still need provider-specific validation before treating them as production evidence.
PubMed/NCBI / Semantic Scholar / UniProt / AlphaFold DB / ESMFold
2026-10-29
Published a reproducible partial reanalysis of the source-labelled PX1 PIN/LMD ex-vivo susceptibility data.
Blocked: The available workbook lacks numeric per-sample read depth and the sample-matched inputs for the paper's adjusted mixed-effects model.
/challenges/001-antimalarial-resistance / 10.1038/s41591-026-04590-5
Problem decomposition
Tier 1
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Tier 2
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Tier 3
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Tier 4
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